Journal
JOURNAL OF NEUROTRAUMA
Volume 26, Issue 6, Pages 861-876Publisher
MARY ANN LIEBERT, INC
DOI: 10.1089/neu.2008.0645
Keywords
biomechanics; blast; brain injury; in-vitro models
Funding
- National Institutes of Health [NS 35172, HD 41699]
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Traumatic brain injury caused by explosive or blast events is currently divided into four phases: primary, secondary, tertiary, and quaternary blast injury. These phases of blast-induced traumatic brain injury (bTBI) are biomechanically distinct, and can be modeled in both in-vivo and in-vitro systems. The purpose of this review is to consider the mechanical phases of bTBI, how these phases are reproduced with in-vitro models, and to review findings from these models to assess how each phase of bTBI can be examined in more detail. Highlighted are some important gaps in the literature that may be addressed in the future to better identify the exact contributing mechanisms for bTBI. These in-vitro models, viewed in combination with in-vivo models and clinical studies, can be used to assess both the mechanisms and possible treatments for this type of trauma.
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