Journal
JOURNAL OF NEUROSURGERY
Volume 117, Issue 3, Pages 546-554Publisher
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/2012.5.JNS091308
Keywords
intracranial aneurysm; tissue engineering; rabbit endothelial progenitor cell; vascular disorders
Categories
Funding
- Alberta Heritage Fund for Medical Research Clinical Fellowship Award
- AANS/CNS Resident Research Award in Cerebrovascular Disease
- Centre for Integration of Medicine
- Howard Hughes Medical Institute Medical Fellows Program
Ask authors/readers for more resources
Object. Recurrence after endovascular coiling of intracranial aneurysms is reported in up to 42% of cases and is attributed to the lack of endothelialization across the neck. In this study the authors used a novel tissue engineering approach to promote endothelialization by seeding endothelial progenitor cells (EPCs) within a fibrin polymer injected endovascularly into the aneurysm. Methods. Experimental aneurysms were created in New Zealand White rabbits and were left untreated, surgically clipped, or embolized with platinum coils, fibrin biopolymer alone, or fibrin combined with autologous cultured EPCs. Results. In aneurysms treated with EPCs, a confluent monolayer of endothelial cells with underlying neointima was demonstrated across the neck at 16 weeks posttreatment, which was not observed with aneurysms treated using the other methods. Conclusions. This novel technique may address reasons for the limited durability of standard coil embolization and provides further avenues for the development of improved devices for the care of patients with aneurysms. (http://thejns.org/doi/abs/10.3171/2012.5.JNS091308)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available