Journal
JOURNAL OF NEUROSURGERY
Volume 113, Issue 2, Pages 161-166Publisher
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/2010.2.JNS09950
Keywords
hyperglycemia; postoperative complication; surgical site infection; glucose; craniotomy
Categories
Funding
- Melvin Burkhardt chair in neurosurgical oncology
- Brain Tumor and Neuro-Oncology Center at the Cleveland Clinic
Ask authors/readers for more resources
Object. In select patient populations, hyperglycemia has been shown to increase the risk of surgical site infection (SSI), whereas stringent glucose control has improved outcomes. To date, no study has focused on whether SSIs in patients with brain tumors undergoing resection are associated with hyperglycemia. Methods. The authors performed a retrospective chart review of patients who underwent a craniotomy after receiving a diagnosis of brain tumor. From 2001 to 2008, 2485 patients underwent a craniotomy for tumor resection at the Brain Tumor & Neuro-Oncology Center at the Cleveland Clinic. Fifty-seven of these patients (2.3%) developed SSIs postoperatively. A matched case-control study design was used, with 57 patients who developed SS's after craniotomy (cases) matched with 57 patients who did not develop SS's (controls). The results were analyzed using both univariate and multivariate conditional logistic regression. Results. Glucose level was not a significant factor in postoperative SSI (p = 0.83) after adjusting for duration of surgery and adherence to antibiotic prophylaxis. However, duration of surgery was significantly associated with postoperative SSI (p = 0.047). Conclusions. For patients who undergo craniotomy for definitive resection of a brain tumor, duration of surgery described more variation in the model to predict SSI than blood glucose levels. (DOI: 10.3171/2010.2.JNS09950)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available