Journal
JOURNAL OF NEUROSURGERY
Volume 110, Issue 3, Pages 508-513Publisher
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/2008.8.JNS08133
Keywords
cost-benefit analysis; cost-effectiveness; mechanical thrombectomy; stroke
Categories
Funding
- national institutes of health (NIH) [K23 NS051372]
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Object. Mechanical thrombectomy is increasingly being used for the treatment of large-vessel ischemic stroke in patients who arrive outside of the 3-hour tissue plasminogen activator time window. In this study, the authors evaluated the cost and effectiveness of mechanical thrombectomy compared with standard medical therapy in patients who are ineligible to receive tissue plasminogen activator. Methods. Clinical Outcomes of an open-label study of mechanical thrombectomy were compared with a hypothetical control group with a lower recanalization rate (18 vs 60%) and a lower rate of symptomatic intracranial hemorrhage (0.6 vs 7.8%) than the active treatment group. A Markov cost-effectiveness model was built to compare the health benefits and costs associated with mechanical thrombectomy compared with standard medical therapy. All probabilities, quality-of-life factors. and costs were estimated from the published literature. Univariate sensitivity analyses were performed to assess how variations in model parameters affect health and economic outcomes. Results. Treatment of acute ischemic stroke with mechanical thrombectomy increased survival time by 0.54 quality-adjusted life years (QALYs), compared with standard medical therapy (2.37 vs 1.83 QALYs), at an increased cost of $6600. This yielded an incremental cost-effectiveness ratio (ICER) of $12,120 per QALY gained, a value generally considered cost-effective. Sensitivity analysis showed that mechanical thrombectomy remained cost-effective (ICER < $50,000,per QALY gained) for all model inputs varied over a reasonable range. except for age at stroke treatment. For patients older than 82 years of age, the treatment was only borderline cost-effective (ICER of $50,000-100,000 per QALY gained). Conclusions. The treatment of large-vessel ischemic stroke with mechanical thrombectomy appears to be cost-effective. These results require validation when data from a randomized, controlled trial of mechanical thrombectomy become available. (DOI: 10.3171/2008.8.JNS08133)
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