Journal
JOURNAL OF NEUROSCIENCE RESEARCH
Volume 87, Issue 3, Pages 599-608Publisher
WILEY
DOI: 10.1002/jnr.21890
Keywords
hypoxia-ischemia; minocycline; neonate; neuroinflammation; neuroprotection
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Minocycline is a second-generation tetracycline and a potential neuroprotective intervention following brain injury. However, despite the recognized beneficial effects of minocycline in a multitude of adult disease states, the clinical application of minocycline in neonates is contentious. Tetracyclines, as a class, are not usually administered to neonates, but there is compelling evidence that minocycline reduces brain injury after neonatal hypoxic-ischemic brain injury. This Review focuses on the evidence for minocycline use in neonates by considering aspects of pharmacology, drug regimens, functional outcomes, and mechanisms of action. (C) 2008 Wiley-Liss, Inc.
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