Journal
JOURNAL OF NEUROSCIENCE RESEARCH
Volume 86, Issue 3, Pages 496-503Publisher
WILEY
DOI: 10.1002/jnr.21461
Keywords
synuclein; neurodegeneration; metal; Parkinson's disease
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Parkinson's disease and some other neurodegenerative disorders are associated with a protein that can aggregate and form fibrils called alpha-synuclein. Like many other proteins associated with neurodegenerative disorders, this protein has no known function, and the mechanism by which it could cause diseases is poorly defined. It was recently suggested that it binds copper. This review assesses what is known about alpha-synuclein and its interaction with metals. (C) 2007 Wiley-Liss, inc.
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