Journal
JOURNAL OF NEUROSCIENCE METHODS
Volume 177, Issue 1, Pages 60-66Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneumeth.2008.09.032
Keywords
Neurophysiology; Prefrontal cortex; Primate; Single-unit recording; Frontal air sinus; Behavioral neurophysiology
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Funding
- NIH
- National Institute of Mental Health
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Neurophysiological research has explored most of the prefrontal cortex of macaque monkeys, but the relatively inaccessible frontal-pole cortex remains unexamined. Here we describe a method for gaining access to the frontal-pole cortex with moveable microelectrodes. The key innovation is a direct approach through the frontal air sinus. In addition, the small size of the frontal-pole cortex in macaques led to the design of a smaller recording chamber than typically used in behavioral neurophysiology. The method has proven successful in two subjects, with no adverse health consequences. Published by Elsevier B.V.
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