Journal
JOURNAL OF NEUROSCIENCE METHODS
Volume 178, Issue 1, Pages 103-115Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneumeth.2008.12.002
Keywords
Pseudorandom stimulation; Fusimotor; Multiple independent inputs; Muscle spindle
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Funding
- Medical Research Council [G0601253] Funding Source: Medline
- MRC [G0601253] Funding Source: UKRI
- Medical Research Council [G0601253] Funding Source: researchfish
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We describe a new method of investigation of the integrative action of fusimotor inputs in mammalian muscle spindles by stimulation of multiple fusimotor axons using independent pseudorandom pulse trains, each of low mean rate with pseudorandomly distributed stimulus intervals. Technically it was feasible only because of the development of (1) a novel, highly efficient approach to functional isolation of fusimotor efferents in ventral-root filaments, which we have called the isodyne strategy; (2) a real-time, microprocessor-based stimulus artefact cancellation device (SACAD): and (3) a highly adjustable, multi-branch stimulation electrode array. The general approach of using multiple, independent, pseudorandom stimulation of several input channels has wider applications in controlled-activation paradigms. (C) 2008 Elsevier B.V. All rights reserved.
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