Journal
JOURNAL OF NEUROSCIENCE METHODS
Volume 169, Issue 1, Pages 23-26Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneumeth.2007.11.026
Keywords
monkey; craniotomy; neurophysiology; silastic; silicone elastomer; granulation tissue; dura mater
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Funding
- NIMH NIH HHS [R01 MH070836-03, K01MH-01902A, MH-070836, MH072059-01A2, K01 MH001902, F31 MH072059, R01 MH070836] Funding Source: Medline
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The maintenance of the sterility of craniotomies for serial acute neurophysiological recordings is exacting and time consuming yet is vital to the health of valuable experimental animals. We have developed a method to seal the craniotomy with surgical grade silicone elastomer (Silastic (R)) in a hermetically sealed chamber. Under these conditions the tissues in the craniotomy and the inside surface of the chamber remain unpopulated by bacteria. The silicone elastomer sealant retarded the growth of granulation tissue on the dura and reduced the procedures required to maintain ideal conditions for neurophysiological recordings. (c) 2007 Elsevier B.V. All rights reserved.
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