Journal
JOURNAL OF NEUROSCIENCE
Volume 34, Issue 46, Pages 15482-15489Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3258-14.2014
Keywords
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Categories
Funding
- Velux Foundation Professorship Grant
- Swiss National Science Foundation Grant [SNF-CR3313-153039]
- SCOPES Grant [IZ73Z0_152496]
- Novartis Foundation Grant
- Bangerter Stiftung
- Synapsis Foundation
- National Institutes of Health Grants [R01DK059418, R01DK074746]
- Fondo Nacional de Desarrollo Cientifico y Tecnologico [1110987, 3130527]
- Millennium Nucleus [RC-120003]
- Ring Initiative [ACT1109]
- Deutsche Forschungsgemeinschaft research Grants [KR 3668/1-1]
- DFG [SPP1757, KR-3668/2-1]
- Dutch Scientific Organisation (NWO-Rubicon)
- Amyloidosis Foundation
- Fondation pour la Recherche Medicale
- National Institutes of Health/National Cancer Institute Grants through the National Institutes of Health Common Fund, the Office of Strategic Coordination/Office of the National Institutes of Health Director [P01 CA069246, CA141150, U19 CA179563]
- Swiss National Science Foundation (SNF) [IZ73Z0_152496] Funding Source: Swiss National Science Foundation (SNF)
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Information exchange executed by extracellular vesicles, including exosomes, is a newly described form of intercellular communication important in the development and physiology of neural systems. These vesicles can be released from cells, are packed with information including signaling proteins and both coding and regulatory RNAs, and can be taken up by target cells, thereby facilitating the transfer of multilevel information. Recent studies demonstrate their critical role in physiological processes, including nerve regeneration, synaptic function, and behavior. These vesicles also have a sinister role in the propagation of toxic amyloid proteins in neurodegenerative conditions, including prion diseases and Alzheimer's and Parkinson's diseases, in inducing neuroinflammation by exchange of information between the neurons and glia, as well as in aiding tumor progression in the brain by subversion of normal cells. This article provides a summary of topics covered in a symposium and is not meant to be a comprehensive review of the subject.
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