Journal
JOURNAL OF NEUROSCIENCE
Volume 34, Issue 39, Pages 12982-12999Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1348-14.2014
Keywords
Alzheimer's disease; endocytosis; inflammation; microglia; neurodegeneration; NF-kappa B
Categories
Funding
- Alzheimer Forschung Initiative e.V.
- Fritz Thyssen Stiftung
- Medical Faculty of University of the Saarland through HOMFOR
- Forschungspreis der Freunde des Universitatsklinikums des Saarlandes
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Alzheimer's disease (AD) is characterized by extracellular amyloid-beta (A beta) deposits and microglia-dominated inflammatory activation. Innate immune signaling controls microglial inflammatory activities and A beta clearance. However, studies examining innate immunity in A beta pathology and neuronal degeneration have produced conflicting results. In this study, we investigated the pathogenic role of innate immunity in AD by ablating a key signaling molecule, IKK beta, specifically in the myeloid cells of TgCRND8 APP-transgenic mice. Deficiency of IKK beta in myeloid cells, especially microglia, simultaneously reduced inflammatory activation andA beta load in the brain and these effects were associated with reduction of cognitive deficits and preservation of synaptic structure proteins. IKK beta deficiency enhanced microglial recruitment to A beta deposits and facilitated A beta internalization, perhaps by inhibiting TGF-beta-SMAD2/3 signaling, but did not affect A beta production and efflux. Therefore, inhibition of IKK beta signaling in myeloid cells improves cognitive functions in AD mice by reducing inflammatory activation and enhancing A beta clearance. These results contribute to a better understanding of AD pathogenesis and could offer a new therapeutic option for delaying AD progression.
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