Journal
JOURNAL OF NEUROSCIENCE
Volume 34, Issue 46, Pages 15490-15496Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3299-14.2014
Keywords
-
Categories
Funding
- National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Diseases Grant [R01 DK048351, P30 DK041301]
- National Institutes of Health/National Institute of Mental Health Grant [R01 MH100556]
- Simons Foundation SFARI Program
- Howard Hughes Medical Institute
- Autism Speaks
Ask authors/readers for more resources
The discovery of the size and complexity of the human microbiome has resulted in an ongoing reevaluation of many concepts of health and disease, including diseases affecting the CNS. A growing body of preclinical literature has demonstrated bidirectional signaling between the brain and the gut microbiome, involving multiple neurocrine and endocrine signaling mechanisms. While psychological and physical stressors can affect the composition and metabolic activity of the gut microbiota, experimental changes to the gut microbiome can affect emotional behavior and related brain systems. These findings have resulted in speculation that alterations in the gut microbiome may play a pathophysiological role in human brain diseases, including autism spectrum disorder, anxiety, depression, and chronic pain. Ongoing large-scale population-based studies of the gut microbiome and brain imaging studies looking at the effect of gut microbiome modulation on brain responses to emotion-related stimuli are seeking to validate these speculations. This article is a summary of emerging topics covered in a symposium and is not meant to be a comprehensive review of the subject.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available