Journal
JOURNAL OF NEUROSCIENCE
Volume 34, Issue 6, Pages 2349-2354Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3620-13.2014
Keywords
adult neurogenesis; circuit; dentate gyrus; GABA; glutamate; synaptic
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Funding
- NIH [T32NS061788, F31NS078887, R01NS064025, R01NS065920, P30 NS047466]
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Adult-generated granule cells (GCs) in the dentate gyrus must establish synapses with preexisting neurons to participate in network activity. To determine the source of early glutamatergic synapses on newborn GCs in adult mice, we examined synaptic currents at the developmental stage when NMDA receptor-mediated silent synapses are first established. We show that hilar mossy cells provide initial glutamatergic synapses as well as disynaptic GABAergic input to adult-generated dentate GCs.
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