Journal
JOURNAL OF NEUROSCIENCE
Volume 33, Issue 16, Pages 6857-6863Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3965-12.2013
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Funding
- Netherlands Genomics Initiative
- MS Research Foundation [08-642]
- ZonMw [LGT.6918]
- Multiple Sclerosis Society of Great Britain and Northern Ireland
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Blood-brain barrier (BBB) dysfunction is a major hallmark of many neurological diseases, including multiple sclerosis (MS). Using a genomics approach, we defined a microRNA signature that is diminished at the BBB of MS patients. In particular, miR-125a-5p is a key regulator of brain endothelial tightness and immune cell efflux. Our findings suggest that repair of a disturbed BBB through microRNAs may represent a novel avenue for effective treatment of MS.
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