Journal
JOURNAL OF NEUROSCIENCE
Volume 33, Issue 9, Pages 4206-4210Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3730-12.2013
Keywords
-
Categories
Funding
- United States Public Health Service Grant [MH18501]
- Cure Huntington's Disease Initiative
Ask authors/readers for more resources
Although the mutated protein causing Huntington's disease (HD) is expressed throughout the body, the major pathology of HD is localized to the striatum of the brain. We previously reported that the striatal-enriched protein Rhes binds the mutated huntingtin protein and enhances its cytotoxicity. We now demonstrate that Rhes-deleted mice are dramatically protected from neurotoxicity and motor dysfunction in a striatal-specific model of HD elicited by 3-nitropropionic acid. This finding suggests that Rhes may, in part, determine the striatal selectivity of HD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available