Journal
JOURNAL OF NEUROSCIENCE
Volume 32, Issue 46, Pages 16496-16502Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3475-12.2012
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Funding
- Vienna Science and Technology Fund [SCIC03]
- Austrian Science Fund [W1205]
- Medical Research Council, United Kingdom
- MRC [MC_U138197107, MC_U138197110] Funding Source: UKRI
- Medical Research Council [MC_U138197107, MC_U138197110] Funding Source: researchfish
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Axo-axonic interneurons, innervating exclusively axon initial segments, and parvalbumin-expressing basket interneurons, targeting somata, dendrites, and spines of pyramidal cells, have been proposed to control neuronal activity in prefrontal circuits. We recorded the spike-timing of identified neurons in the prelimbic cortex of anesthetized rats, and show that axo-axonic cells increase their firing during tail pinch-induced brain state-activation. In addition, axo-axonic cells differ from other GABAergic parvalbumin-expressing cells in their spike timing during DOWN-to UP-state transitions of slow oscillations and in their coupling to gamma and spindle oscillations. The distinct firing dynamics and synaptic targets of axo-axonic and other parvalbumin-expressing cells provide differential contributions to the temporal organization of prefrontal networks.
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