Journal
JOURNAL OF NEUROSCIENCE
Volume 32, Issue 25, Pages 8696-8702Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1692-12.2012
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Funding
- NIMH [1F32MH092101-01A1]
- National Alliance for Research on Schizophrenia and Depression (NARSAD)
- New York Stem Cell Initiative, NIH [R01 MH068542]
- Hope for Depression Research Foundation
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Adult-generated granule cells (GCs) in the dentate gyrus (DG) exhibit a period of heightened plasticity 4-6 weeks postmitosis. However, the functional contribution of this critical window of plasticity to hippocampal neurogenesis and behavior remains unknown. Here, we show that deletion of NR2B-containing NMDA receptors from adult-born GCs impairs a neurogenesis-dependent form of LTP in the DG and reduces dendritic complexity of adult-born GCs, but does not impact their survival. Mice in which the NR2B-containing NMDA receptor was deleted from adult-born GCs did not differ from controls in baseline anxiety-like behavior or discrimination of very different contexts, but were impaired in discrimination of highly similar contexts. These results indicate that NR2B-dependent plasticity of adult-born GCs is necessary for fine contextual discrimination and is consistent with their proposed role in pattern separation.
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