Journal
JOURNAL OF NEUROSCIENCE
Volume 31, Issue 49, Pages 18180-18184Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4960-11.2011
Keywords
-
Categories
Funding
- Bundesministerium fur Bildung und Forschung (NGFNplus MooDs)
- Deutsche Forschungsgemeinschaft [SFB 636-B7]
Ask authors/readers for more resources
Alzheimer's disease is a devastating, common, progressive dementia with considerable heritability. Recently, a genetic variant associated with the disease was discovered at CLU (rs11136000) with genome-wide support. Here we show, using an imaging genetics approach in a large genotyped sample, that healthy carriers of the variant exhibit altered coupling between hippocampus and prefrontal cortex during memory processing, mirroring clinical evidence of disturbed connectivity in patients and providing a neurogenetic mechanism for CLU-associated risk and protection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available