Journal
JOURNAL OF NEUROSCIENCE
Volume 31, Issue 46, Pages 16826-16832Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4184-11.2011
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Funding
- National Institutes of Health (NIH/NINDS) [R01-NS052505-04]
- Dunn Research Fund
- NIH/NIBIB [EB002095]
- NIH [S10 RR19186]
- [NS046565]
- [R01 NS046308]
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The human brain thalami play essential roles in integrating cognitive, sensory, and motor functions. In multiple sclerosis (MS), quantitative magnetic resonance imaging (qMRI) measurements of the thalami provide important biomarkers of disease progression, but late development and aging confound the interpretation of data collected from patients over a wide age range. Thalamic tissue volume loss due to natural aging and its interplay with lesion-driven pathology has not been investigated previously. In this work, we used standardized thalamic volumetry combined with diffusion tensor imaging, T2 relaxometry, and lesion mapping on large cohorts of controls (N = 255, age range = 6.2-69.1 years) and MS patients (N = 109, age range = 20.8-68.5 years) to demonstrate early age- and lesion-independent thalamic neurodegeneration.
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