Journal
JOURNAL OF NEUROSCIENCE
Volume 30, Issue 13, Pages 4585-4589Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4939-09.2010
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Funding
- German Research Foundation [He 1128/15-1]
- Bundesministerium fur Bildung und Forschung
- Graduiertenkolleg 1123 Cellular Mechanisms of Learning and Memory Consolidation in the Hippocampal Formation, Boehringer Ingelheim Fonds
- Royal Society of Edinburgh/Lloyds TSB
- Engineering and Physical Sciences Research Council/Medical Research Council
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In both humans and rodents, the external environment is encoded in the form of cognitive maps. Neurons in the medial entorhinal cortex (mEC) represent spatial locations in a sequence of grid-like patterns scaled along the dorsal-ventral axis. The grid spacing correlates with the intrinsic resonance frequencies of stellate cells in layer II of mEC. We investigated the development of frequency preferences in these cells from weaning to adulthood using patch-clamp and sharp microelectrode recordings. We found that the dorsal-ventral gradient of stellate cell properties and frequency preferences exists before animals are able to actively explore their environment. In the transition to adulthood, cells respond faster and become less excitable, and the range of intrinsic resonance frequencies in the population expands in the dorsal direction. This is likely to reflect both the growth of the brain and the expansion of the internal representation caused by new exploratory experience.
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