Journal
JOURNAL OF NEUROSCIENCE
Volume 30, Issue 31, Pages 10380-10390Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0647-10.2010
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Funding
- National Institutes of Health-National Institute on Deafness and Other Communication Disorders [R01-01641]
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Neurons in the auditory system respond to recent stimulus-level history by adapting their response functions according to the statistics of the stimulus, partially alleviating the so-called dynamic-range problem. However, the mechanism and source of this adaptation along the auditory pathway remain unknown. Inclusion of power-law dynamics in a phenomenological model of the inner hair cell (IHC)-auditory nerve (AN) synapse successfully explained neural adaptation to sound-level statistics, including the time course of adaptation of the mean firing rate and changes in the dynamic range observed in AN responses. A direct comparison between model responses to a dynamic stimulus and to an inversely gated static background suggested that AN dynamic-range adaptation largely results from the adaptation produced by the response history. These results support the hypothesis that the potential mechanism underlying the dynamic-range adaptation observed at the level of the auditory nerve is located peripheral to the spike generation mechanism and central to the IHC receptor potential.
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