Journal
JOURNAL OF NEUROSCIENCE
Volume 30, Issue 29, Pages 9788-9792Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1513-10.2010
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Successful remembering involves both hindering irrelevant information from entering working memory (WM) and actively maintaining relevant information online. Using a voxelwise lesion-behavior brain mapping approach in stroke patients, we observed that lesions of the left basal ganglia render WM susceptible to irrelevant information. Lesions of the right prefrontal cortex on the other hand make it difficult to keep more than a few items in WM. These findings support basal ganglia-prefrontal cortex models of WM where by the basal ganglia play a gatekeeper role and allow only relevant information to enter prefrontal cortex where this information then is actively maintained in WM.
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