Journal
JOURNAL OF NEUROSCIENCE
Volume 30, Issue 34, Pages 11501-11505Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1593-10.2010
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Funding
- National Institutes of Health [R01 NS028709, R01 EY05477, R01 EY09024, P01 HD29587]
- Canadian Institutes for Health Research
- Alberta Heritage Foundation for Medical Research
- Canada Research Chairs
- Pew Charitable Trusts
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NMDA receptors are typically excited by a combination of glutamate and glycine. Here we describe excitatory responses in CNS myelin that are gated by a glycine agonist alone and mediated by NR1/NR3 NMDA receptor subunits. Response properties include activation by D-serine, inhibition by the glycine-site antagonist CNQX, and insensitivity to the glutamate-site antagonist D-APV. D-Serine responses were abrogated in NR3A-deficient mice. Our results suggest the presence of functional NR1/NR3 receptors in CNS myelin.
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