Journal
JOURNAL OF NEUROSCIENCE
Volume 29, Issue 5, Pages 1424-1433Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.4817-08.2009
Keywords
neurometabolic coupling; metabolism; oxygen; olfactory bulb; neurovascular coupling; odor
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Funding
- NIDCD NIH HHS [R01 DC000210-11, R01 DC000210] Funding Source: Medline
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The relationship between metabolism of neuronal activity, microvascular organization, and blood flow dynamics is critical for interpreting functional brain imaging. Here we used the rat dorsal olfactory bulb as a model to determine in vivo the correlation between action potential propagation, synaptic transmission, oxygen consumption, and capillary density during odor stimulation. We find that capillary lumen occupies similar to 3% of the glomerular volume, where synaptic transmission occurs, and only 0.1% of the overlying nerve layer. In glomeruli, odor triggers a local early decrease in tissue oxygen partial pressure that results principally from dendritic activation rather than from firing of axon terminals, transmitter release or astrocyte activation. In the nerve layer, action potential propagation does not generate local changes in tissue oxygen partial pressure. We conclude that capillary density is tightly correlated with the oxidative metabolism of synaptic transmission, and suggest that action potential propagation operates mainly anaerobically.
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