Journal
JOURNAL OF NEUROSCIENCE
Volume 29, Issue 43, Pages 13613-13620Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.2041-09.2009
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Funding
- National Institutes of Health [MH61975, MH062196, T32 NS054575, NS033221, F32 NS50067-01A1]
- National Science Foundation [SBE0354378]
- Dana Foundation Grant Intracranial EEG
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A fundamental question in neuroscience concerns the relation between the spiking of individual neurons and the aggregate electrical activity of neuronal ensembles as seen in local field potentials (LFPs). Because LFPs reflect both spiking activity and subthreshold events, this question is not simply one of data aggregation. Recording from 20 neurosurgical patients, we directly examined the relation between LFPs and neuronal spiking. Examining 2030 neurons in widespread brain regions, we found that firing rates were positively correlated with broadband (2-150 Hz) shifts in the LFP power spectrum. In contrast, narrowband oscillations correlated both positively and negatively with firing rates at different recording sites. Broadband power shifts were a more reliable predictor of neuronal spiking than narrowband power shifts. These findings suggest that broadband LFP power provides valuable information concerning neuronal activity beyond that contained in narrowband oscillations.
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