Journal
JOURNAL OF NEUROSCIENCE
Volume 29, Issue 31, Pages 9918-9929Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1378-09.2009
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Funding
- National Institutes of Health/National Institute of Mental Health (NIH/NIMH) [MH051570, MH71702]
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Previous research indicates a critical role of the hippocampus in memory for events in the context in which they occur. However, studies to date have not provided compelling evidence that hippocampal neurons encode event-context conjunctions directly associated with this kind of learning. Here we report that, as animals learn different meanings for items in distinct contexts, individual hippocampal neurons develop responses to specific stimuli in the places where they have differential significance. Furthermore, this conjunctive coding evolves in the form of enhanced item-specific responses within a subset of the preexisting spatial representation. These findings support the view that conjunctive representations in the hippocampus underlie the acquisition of context-specific memories.
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