Journal
JOURNAL OF NEUROSCIENCE
Volume 29, Issue 41, Pages 12764-12767Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3566-09.2009
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Funding
- National Institute of Neurological Disorders and Stroke (NINDS)
- Kirby Foundation
- NINDS
- National Institutes of Health Intramural Research Program
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BDNF has pleiotropic effects on neuronal development and synaptic plasticity that underlie circuit formation and cognitive function. Recent breakthroughs reveal that neuronal activity regulates BDNF cell biology, including Bdnf transcription, dendritic targeting and trafficking of BDNF mRNA and protein, and secretion and extracellular conversion of proBDNF to mature BDNF. Defects in these mechanisms contribute differentially to cognitive dysfunction and anxiety-like behaviors. Here we review recent studies, presented at a symposium at Neuroscience 2009, that describe regulatory mechanisms that permit rapid and dynamic refinement of BDNF actions in neurons.
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