Journal
JOURNAL OF NEUROSCIENCE
Volume 29, Issue 21, Pages 6926-6931Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1396-09.2009
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Funding
- Medical Research Council
- Marie Curie Intra-European Fellowship within the 6th European Community Framework Programme
- Royal Society International Incoming Short Visits
- MRC [G0700399, G0600994, G0802146] Funding Source: UKRI
- Medical Research Council [G0802146, G0600994, G0700399] Funding Source: researchfish
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Medial frontal cortex (MFC) is crucial when actions have to be inhibited, reprogrammed, or selected under conflict, but the precise mechanism by which it operates is unclear. Importantly, how and when the MFC influences the primary motor cortex (M1) during action selection is unknown. Using paired-pulse transcranial magnetic stimulation, we investigated functional connectivity between the presupplementary motor area (pre-SMA) part of MFC and M1. We found that functional connectivity increased in a manner dependent on cognitive context: pre-SMA facilitated the motor evoked-potential elicited by M1 stimulation only during action reprogramming, but not when otherwise identical actions were made in the absence of conflict. The effect was anatomically specific to pre-SMA; it was not seen when adjacent brain regions were stimulated. We discuss implications for the anatomical pathways mediating the observed effects.
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