Journal
JOURNAL OF NEUROSCIENCE
Volume 29, Issue 24, Pages 7694-7705Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.5537-08.2009
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Funding
- National Institutes of Health [NS046456, MH078833]
- California Institute of Regenerative Medicine
- Christopher Reeve Foundation
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Radial glial cells (RGCs) in the developing cerebral cortex are progenitors for neurons and glia, and their processes serve as guideposts for migrating neurons. So far, it has remained unclear whether RGC processes also control the function of RGCs more directly. Here, we show that RGC numbers and cortical size are reduced in mice lacking beta 1 integrins in RGCs. TUNEL stainings and time-lapse video recordings demonstrate that beta 1-deficient RGCs processes detach from the meningeal basement membrane (BM) followed by apoptotic death of RGCs. Apoptosis is also induced by surgical removal of the meninges. Finally, mice lacking the BM components laminin alpha 2 and alpha 4 show defects in the attachment of RGC processes at the meninges, a reduction in cortical size, and enhanced apoptosis of RGC cells. Our findings demonstrate that attachment of RGC processes at the meninges is important for RGC survival and the control of cortical size.
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