Journal
JOURNAL OF NEUROSCIENCE
Volume 29, Issue 43, Pages 13710-13719Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3022-09.2009
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Funding
- National Institute of Neurological Disorders and Stroke [R01NS047191, 1F30NS051864]
- Sontag Foundation Distinguished Scholar Award [6- FY07- 401]
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The mechanisms underlying the timing of the laminar fate decisions during cortical neurogenesis remain poorly understood. Here we show that beta-catenin signaling in cortical neural precursors can regulate the laminar fate of their daughters. In ventricular zone neural precursors, beta-catenin signaling is higher when deep-layer neurons are being generated and lower when upper-layer neurons are being generated. Overactivation of beta-catenin in cortical precursors midway through corticogenesis increased the relative production of deep-layer neurons, while inhibition of signaling increased the relative production of upper-layer neurons. Furthermore, in late-gestation upper-layer precursors, overactive beta-catenin signaling was able to partially restore production of deep-layer neurons. These observations suggest that increased beta-catenin signaling can reset the timing of cortical precursors to promote the production of deep-layer neurons, while inhibition of beta-catenin signaling advances the timing to promote upper-layer production.
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