Journal
JOURNAL OF NEUROSCIENCE
Volume 29, Issue 16, Pages 5170-5182Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.5569-08.2009
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Funding
- State Key Program for Basic Research of China [2006CB500704, 2007CB947100]
- 863 Research Program [2006AA02A114]
- Natural Science Foundation of China [30525041, 30623003, 30621130075]
- Shanghai Metropolitan Fund for Research and Development [07DJ14005]
- Institute of Biochemistry and Cell Biology, Shanghai, China
- Medical Research Council [MC_U117570533] Funding Source: researchfish
- MRC [MC_U117570533] Funding Source: UKRI
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Mesodiencephalic dopaminergic (mDA) neurons are critical for movement control and other physiological activities. However, the molecular mechanisms underlying their development are poorly understood. We aimed to establish the expression profiles of genes involved in this process and unravel genetic programs that control late development of mDA neurons. We compared genome-wide gene expression profiles of developing mouse ventral mesencephalon (VM) using microarrays. We identified a set of genes that show spatially and temporally restricted expression in the VM in an Ngn2 ( neurogenin 2)-dependent manner and are potentially important for mDA neuron development. Functional analysis on mice lacking the VM-specific gene early B-cell factor 1 (Ebf1) revealed that Ebf1 is essential for the terminal migration of mDA neurons in the substantia nigra pars compacta. Thus, we identified a set of VM-enriched genes that are important for mDA neuron development. Our analysis also provides a genetic framework for further investigation of the molecular mechanisms mediating mDA neuron development.
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