Journal
JOURNAL OF NEUROSCIENCE
Volume 28, Issue 38, Pages 9414-9425Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3196-08.2008
Keywords
h current; grid cells; entorhinal cortex; stellate cells; subthreshold oscillations; HCN subunit
Categories
Funding
- National Institute of Mental Health (NIMH) [MH61492, MH60013, MH71702]
- Silvio O. Conte Center
- National Science Foundation [0354378]
- National Institute on Drug Abuse [DA16454]
- Direct For Social, Behav & Economic Scie [0354378] Funding Source: National Science Foundation
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Chronic recordings in the medial entorhinal cortex of behaving rats have found grid cells, neurons that fire when the rat is in a hexagonal array of locations. Grid cells recorded at different dorsal-ventral anatomical positions show systematic changes in size and spacing of firing fields. To test possible mechanisms underlying these differences, we analyzed properties of the hyperpolarization-activated cation current I-h in voltage-clamp recordings from stellate cells in entorhinal slices from different dorsal-ventral locations. The time constant of h current was significantly different between dorsal and ventral neurons. The time constant of h current correlated with membrane potential oscillation frequency and the time constant of the sag potential in the same neurons. Differences in h current could underlie differences in membrane potential oscillation properties and contribute to grid cell periodicity along the dorsal-ventral axis of medial entorhinal cortex.
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