Journal
JOURNAL OF NEUROSCIENCE
Volume 28, Issue 14, Pages 3804-3813Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0224-08.2008
Keywords
subventricular zone; neural stem cells; neural progenitor cells; ependymal cells; repair; aging
Categories
Funding
- NINDS NIH HHS [NS050338, NS45894, R01 NS050338-02, R01 NS050338] Funding Source: Medline
Ask authors/readers for more resources
The subventricular zone ( SVZ) of the adult mouse brain is a narrow stem cell niche that lies along the length of the lateral wall of the lateral ventricles. The SVZ supports neurogenesis throughout adulthood; however, with increasing age, the ventral SVZ deteriorates and only the dorsolateral SVZ remains neurogenic. Associated with the elderly dorsolateral SVZ, we reported previously an increased number of astrocytes interposed within the adjacent ependymal lining. Here, we show that astrocytes integrated within the ependyma are dividing, BrdU-labeled astrocytes that share cellular adherens with neighboring ependymal cells. By tracking BrdU-labeled astrocytes over time, we observed that, as they incorporated within the ependyma, they took on antigenic and morphologic characteristics of ependymal cells, suggesting a novel form of SVZ-supported regenerative repair in the aging brain. A similar form of SVZ-mediated ependyma repair was also observed in young mice after mild ependymal cell denudation with low dosages of neuraminidase. Together, this work identifies a novel non-neuronal mechanism of regenerative repair by the adult SVZ.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available