Journal
JOURNAL OF NEUROSCIENCE
Volume 28, Issue 38, Pages 9536-9544Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1495-08.2008
Keywords
actin; angiotensin II; cytoskeleton; osmotic pressure; osmosensitivity; supraoptic nucleus; vasopressin
Categories
Funding
- Canadian Institutes of Health Research Operating [MOP-9939]
- McGill University Health Center Research Institute
- Heart and Stroke Foundation of Canada
- Fonds de la Recherche en Sante du Que
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Osmosensory neurons transduce osmotic signals into a neural spike code that commands behavioral and endocrine responses that mediate body fluid homeostasis. Although changes in osmoregulatory reflex gain are known to occur under physiological and pathological conditions, the basis for this modulation is unknown. Here, we show that angiotensin II amplifies osmosensory transduction by enhancing the proportional relationship between osmolality, receptor potential, and action potential firing in rat supraoptic nucleus neurons. This effect is mediated by a phospholipase C-and protein kinase C-dependent increase in cellular mechanosensitivity that is associated with a rapid increase in cortical actin filament density. Preventing this increase with cytochalasin D eliminated the enhancement of mechanosensitivity, whereas enhancing actin filament density with jasplakinolide potentiated mechanosensitivity and occluded the effects of angiotensin II. These results indicate that a receptor-mediated increase in cortical actin density can enhance osmosensitivity in acutely isolated supraoptic neurons.
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