Journal
JOURNAL OF NEUROSCIENCE
Volume 28, Issue 43, Pages 11003-11014Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3285-08.2008
Keywords
myelin; axoglial junction; paranode; septate-like junctions; Caspr; neurofascin
Categories
Funding
- Multiple Sclerosis Society of Canada
- Canadian Institutes of Health Research
- Montreal Neurological Institute
- Killam Foundation
- Fonds de la Recherche en Sante du Quebec
Ask authors/readers for more resources
Paranodal axoglial junctions are essential for the segregation of myelinated axons into distinct domains and efficient conduction of action potentials. Here, we show that netrin-1 and deleted in colorectal cancer (DCC) are enriched at the paranode in CNS myelin. We then address whether netrin-1 signaling influences paranodal adhesion between oligodendrocytes and axons. In the absence of netrin-1 or DCC function, oligodendroglial paranodes initially develop and mature normally but later become disorganized. Lack of DCC or netrin-1 resulted in detachment of paranodal loops from the axonal surface and the disappearance of transverse bands. Furthermore, the domain organization of myelin is compromised in the absence of netrin-1 signaling: K+ channels inappropriately invade the paranodal region, and the normally restricted paranodal distribution of Caspr expands longitudinally along the axon. Our findings identify an essential role for netrin-1 and DCC regulating the maintenance of axoglial junctions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available