Journal
JOURNAL OF NEURORADIOLOGY
Volume 40, Issue 2, Pages 89-93Publisher
MASSON EDITEUR
DOI: 10.1016/j.neurad.2012.04.001
Keywords
Primary open-angle glaucoma; White matter; DTI; Tract-based spatial statistics
Funding
- Natural Science Foundation of China [30870697]
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Background and purpose: The present study was designed to map the alteration of white matter in primary open-angle glaucoma (POAG) by applying tract-based spatial statistics (TBSS) analysis. Methods: Diffusion tensor imaging (DTI) data from MRI brain scans were collected from 15 POAG patients and 15 gender- and age-matched non-glaucoma controls using a SIEMENS Trio 3.0-Tesla scanner. For the white-matter analysis, DTI images were processed using FSL software (http://www.fmrib.ox.ac.uk/fsl/index.html). Fractional anisotropy (FA) between the POAG and control groups was compared by TBSS analysis corrected for multiple comparisons using threshold-free cluster enhancement (TFCE). Results: Compared with non-glaucoma subjects, the occipital white matter in POAG patients had significantly lower FA values (p<0.05, corrected). Conclusion: The change in white-matter FA may indicate atrophy of the visual cortex that may be important in the diagnosis and treatment of POAG patients. (C) 2012 Elsevier Masson SAS. All rights reserved.
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