Journal
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
Volume 26, Issue 4, Pages 323-328Publisher
AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.neuropsych.11020047
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Funding
- NIH [R01 MH 065134]
- Tokai University, Kanagawa, Japan
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This study examined the efficacy of antidepressant treatment for preventing the onset of generalized anxiety disorder (GAD) among patients with recent stroke. Of 799 patients assessed, 176 were randomized, and 149 patients without evidence of GAD at the initial visit were included in this doubleblind treatment with escitalopram (N=47) or placebo (N=49) or non-blinded problem-solving therapy (PST; 12 total sessions; N=53). Participants given placebo over 12 months were 4.95 times more likely to develop GAD than patients given escitalopram and 4.00 times more likely to develop GAD than patients given PST. Although these results should be considered preliminary, the authors found that both escitalopram and PST were effective in preventing new onset of post-stroke GAD.
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