Journal
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
Volume 23, Issue 1, Pages 6-15Publisher
AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.neuropsych.23.1.6
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Funding
- Sam and Rose Stein Institute for Research on Aging
- NIMH [MH019934]
- Advanced Center for Innovation in Services and Interventions Research [P30 MH080002]
- Vietnam Era Twin Study of Aging (VETSA) MRI Study [AG01834, AG01836, AG022381]
- VA
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Unimpaired cognition is an important feature of successful aging. Differences in cognitive performance among healthy older adults may be related to differences in brain structure. The authors reviewed the literature to examine the relationship between brain-structure size and cognitive performance in older adults. Eighty-three percent of studies found at least one positive relationship between these factors; however, findings were variable. Positive relationships emerged most consistently between the hippocampal formation and global cognition and memory and between frontal measures and executive function. Additional longitudinal study is needed to further evaluate structure-cognition relationships in older adulthood and across the adult lifespan. (The Journal of Neuropsychiatry and Clinical Neurosciences 2011; 23:6-15)
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