Journal
JOURNAL OF NEUROPHYSIOLOGY
Volume 110, Issue 12, Pages 2679-2688Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.01015.2012
Keywords
stimulus-specific adaptation; human auditory cortex; rapid receptive-field plasticity; electroencephalography; mismatch negativity
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Funding
- Medical Research Council
- Grindley Grant of the Experimental Psychology Society
- MRC [MC_U135097128] Funding Source: UKRI
- Medical Research Council [MC_U135097128] Funding Source: researchfish
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The neural response to a sensory stimulus tends to be more strongly reduced when the stimulus is preceded by the same, rather than a different, stimulus. This stimulus-specific adaptation (SSA) is ubiquitous across the senses. In hearing, SSA has been suggested to play a role in change detection as indexed by the mismatch negativity. This study sought to test whether SSA, measured in human auditory cortex, is caused by neural fatigue (reduction in neural responsiveness) or by sharpening of neural tuning to the adapting stimulus. For that, we measured event-related cortical potentials to pairs of pure tones with varying frequency separation and stimulus onset asynchrony (SOA). This enabled us to examine the relationship between the degree of specificity of adaptation as a function of frequency separation and the rate of decay of adaptation with increasing SOA. Using simulations of tonotopic neuron populations, we demonstrate that the fatigue model predicts independence of adaptation specificity and decay rate, whereas the sharpening model predicts interdependence. The data showed independence and thus supported the fatigue model. In a second experiment, we measured adaptation specificity after multiple presentations of the adapting stimulus. The multiple adapters produced more adaptation overall, but the effect was more specific to the adapting frequency. Within the context of the fatigue model, the observed increase in adaptation specificity could be explained by assuming a 2.5-fold increase in neural frequency selectivity. We discuss possible bottom-up and top-down mechanisms of this effect.
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