Journal
JOURNAL OF NEUROPHYSIOLOGY
Volume 101, Issue 4, Pages 1876-1882Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.91002.2008
Keywords
-
Categories
Funding
- National Institue of Mental Health [MH-60131]
- Tourette Syndrome Association
Ask authors/readers for more resources
Gruber AJ, Powell EM, O'Donnell P. Cortically activated interneurons shape spatial aspects of cortico-accumbens processing. J Neurophysiol 101: 1876-1882, 2009. First published January 28, 2009; doi: 10.1152/jn.91002.2008. Basal ganglia circuits are organized as parallel loops that have been proposed to compete in a winner-take-all fashion to determine the appropriate behavioral outcome. However, limited experimental support for strong lateral inhibition mechanisms within striatal regions questions this model. Here, stimulation of the prefrontal cortex (PFC) using naturally occurring bursty patterns inhibited firing in most nucleus accumbens (NA) projection neurons. When an excitatory response was observed for one stimulation site, neighboring PFC sites evoked inhibition in the same neuron. Furthermore, PFC stimulation activated interneurons, and PFC-evoked inhibition was blocked by GABA A antagonists in corticoaccumbens slice preparations. Thus bursting PFC activity recruits local inhibition in the NA, shaping responses of projection neurons with a topographical arrangement that allows inhibition among parallel corticoaccumbens channels. The data indicate a high order of information processing within striatal circuits that should be considered in models of basal ganglia function and disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available