Journal
JOURNAL OF NEUROPHYSIOLOGY
Volume 99, Issue 1, Pages 277-283Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00563.2007
Keywords
-
Categories
Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH079504] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [R01DC005798] Funding Source: NIH RePORTER
- NIDCD NIH HHS [R01-DC-005798] Funding Source: Medline
- NIMH NIH HHS [R01 MH079504, R01-MH-079504, R01 MH079504-02] Funding Source: Medline
Ask authors/readers for more resources
Use of spike timing to encode information requires that neurons respond with high temporal precision and with high reliability. Fast fluctuating stimuli are known to result in highly reproducible spike times across trials, whereas constant stimuli result in variable spike times. Here, we first studied mathematically how spike-time reliability depends on the rapidness of aperiodic stimuli. Then, we tested our theoretical predictions in computer simulations of neuron models (Hodgkin-Huxley and modified quadratic integrate-and-fire), as well as in patch-clamp experiments with real neurons (mitral cells in the olfactory bulb and pyramidal cells in the neocortex). As predicted by our theory, we found that for firing frequencies in the beta/gamma range, spike-time reliability is maximal when the time scale of the input fluctuations (autocorrelation time) is in the range of a few milliseconds (2-5 ms), coinciding with the time scale of fast synapses, and decreases substantially for faster and slower inputs. Finally, we comment how these findings relate to mechanisms causing neuronal synchronization.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available