Journal
JOURNAL OF NEUROPHYSIOLOGY
Volume 100, Issue 2, Pages 1147-1151Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.01204.2007
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- Intramural NIH HHS Funding Source: Medline
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The effect of N-arachidonoyl L-serine (ARA-S), a recently discovered lipoamino acid found in the CNS, on N-type Ca2+ channels of rat sympathetic ganglion neurons was determined using whole cell patch clamp. Application of ARA-S produced a rapid and reversible augmentation of Ca2+ current that was voltage dependent and resulted from a hyperpolarizing shift in the activation curve. ARA-S did not influence G protein modulation of Ca2+ channels and appeared to act independently of G-protein-coupled receptors. These findings provide a foundation for investigating possible roles for ARA-S in nervous system function.
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