Journal
JOURNAL OF NEUROPHYSIOLOGY
Volume 99, Issue 2, Pages 787-798Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/jn.00658.2007
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Funding
- Medical Research Council [G0601581] Funding Source: researchfish
- MRC [G0601581] Funding Source: UKRI
- Medical Research Council [G0601581] Funding Source: Medline
- NINDS NIH HHS [R01-NS-445671-01] Funding Source: Medline
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The spatial resolution of hemodynamic-based neuroimaging techniques, including functional magnetic resonance imaging, is limited by the degree to which neurons regulate their blood supply on a fine scale. Here we investigated the spatial detail of neurovascular events with a combination of high spatiotemporal resolution two-dimensional spectroscopic optical imaging, multichannel electrode recordings and cytochrome oxidase histology in the rodent whisker barrel field. After mechanical stimulation of a single whisker, we found two spatially distinct cortical hemodynamic responses: a transient response in the upstream branches of surface arteries and a later highly localized increase in blood volume centered on the activated cortical column. Although the spatial representation of this localized response exceeded that of a single barrel, the spread of hemodynamic activity accurately reflected the neural response in neighboring columns rather than being due to a passive overspill. These data confirm hemodynamics are capable of providing accurate single-condition maps of neural activity.
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