Journal
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Volume 70, Issue 4, Pages 243-252Publisher
OXFORD UNIV PRESS INC
DOI: 10.1097/NEN.0b013e318211488e
Keywords
Insomnia; Narcolepsy; Neurodegenerative diseases; Neuropathology; Prion diseases; REM sleep behavior disorders; Sleep disorders
Categories
Funding
- Institut de Veille Sanitaire
- Direction de l'hospitalisation et de l'organisation du soin
- French Ministere de la Sante et des Sports
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Sleep disorders are important manifestations of neurodegenerative diseases and sometimes are clinically evident well before the onset of other neurological manifestations. This review addresses the neuroanatomical basis and the mechanisms of sleep regulation in humans in relation to the neuropathology of entities associated with sleep disturbances in selected diseases, including Alzheimer disease, progressive supranuclear palsy, Lewy body disorders, multiple-system atrophy, and fatal familial insomnia. This includes abnormalities of circadian rhythm, insomnia, narcolepsy, rapid eye movements sleep behavior disorders, and excessive daytime sleepiness.
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