Journal
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Volume 69, Issue 12, Pages 1210-1219Publisher
OXFORD UNIV PRESS INC
DOI: 10.1097/NEN.0b013e3181ffc420
Keywords
Animal model; Epilepsy; Epileptogenesis; Hippocampus; Inflammation; Seizure; Virus
Categories
Funding
- Robert and Joyce Rice (Salt Lake City, UT)
- Margolis Foundation (Salt Lake City, UT)
- Citizens United for Research in Epilepsy
- National Institutes of Health [1R01NS065714]
- Epilepsy Foundation
- American Epilepsy Society
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Viral infection of the central nervous system can lead to long-term neurologic defects, including increased risk for the development of epilepsy. We describe the development of the first mouse model of viral-induced epilepsy after intracerebral infection with Theiler's murine encephalomyelitis virus. Mice were monitored with long-term video-electroencephalogram at multiple time points after infection. Most mice exhibited short-term symptomatic seizures within 3 to 7 days of infection. This was followed by a distinct latent period in which no seizures were observed. Prolonged video-electroencephalogram recordings at 2, 4, and 7 months after the initial infection revealed that a significant proportion of the mice developed profound, spontaneous epileptic seizures. Neuropathologic examination revealed hippocampal sclerosis in animals with epilepsy. Theiler's murine encephalomyelitis virusYinfected C57BL/6 mice represent a novel hit-and-run model to investigate mechanisms underlying viral-induced short-term symptomatic seizures, epileptogenesis, and epilepsy. Importantly, this model will also be useful to investigate novel therapies for the treatment and prevention of epilepsy.
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