Journal
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Volume 67, Issue 12, Pages 1205-1212Publisher
OXFORD UNIV PRESS INC
DOI: 10.1097/NEN.0b013e31818fc72f
Keywords
Aging; Cerebral cortex; Neurons; Stereology
Categories
Funding
- Massachusetts Alzheimer Disease Research Center [AG05134, AG09487, AG004390, R01-AG021133, R21-AG023661, R03-AG024633]
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Cerebral volume loss has long been associated with normal aging, bill Whether this is due to aging itself or to age-related diseases, including incipient Alzheimer disease, is uncertain. To understand the changes that occur in the aging brain, we examined the cerebral cortex of 27 normal individuals ranging in age from 56 to 103 years. None fulfilled the criteria for the neuropathologic diagnosis of, Alzheimer disease or other neurodegenerative disease. Seventeen of the elderly participants had cognitive testing an average of 6.7 months prior to death. we used quantitative approaches to analyze cortical thickness, neuronal number, and density. Frontal and temporal neocortical regions had clear evidence of cortical thinning with age, but total neuronal numbers in frontal and temporal neocortical regions remained relatively constant during a 50-year age range. These data suggest that loss of neuronal and dendritic architecture, rather than loss of neurons. underlies neocortical volume loss with increasing age in the absence of Alzheimer disease.
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