Journal
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
Volume 67, Issue 9, Pages 829-837Publisher
OXFORD UNIV PRESS INC
DOI: 10.1097/NEN.0b013e318184482d
Keywords
autism; copy number variation (CNV); endophenotype; genetic
Categories
Funding
- [K12RR023248]
- [R03MH079998]
- [Autism Speaks]
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Despite compelling evidence from twin and family studies indicating a strong genetic involvement in the etiology of autism, the unequivocal detection of autism susceptibility genes remains an elusive goal. The purpose of this review is to evaluate the current state of autism genetics research, with attention focused on new techniques and analytic approaches. We first present a brief overview of evidence for the genetic basis of autism, followed by an appraisal of linkage and candidate Cleric study findings and consideration of new analytic approaches to the study of complex psychiatric conditions, namely, genome-wide association studies, assessment of structural variation within the genome, and the incorporation of endophenotypes in genetic analysis.
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