Journal
JOURNAL OF NEUROLOGY
Volume 261, Issue 8, Pages 1552-1558Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-014-7377-9
Keywords
Multiple sclerosis (MS) fatigue; Quality of life; transcranial direct current stimulation (tDCS); Primary somatosensory cortex (S1); Cortical excitability
Categories
Funding
- FISM-Fondazione Italiana Sclerosi Multipla [2011/R/32]
- Ministry of Health [GR-2008-1138642]
- MIUR [2010SH7H3F]
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Multiple sclerosis-related fatigue is highly common and often refractory to medical therapy. Ten fatigued multiple sclerosis patients received two blocks of 5-day anodal bilateral primary somatosensory areas transcranial direct current stimulation in a randomized, double-blind sham-controlled, cross-over study. The real neuromodulation by a personalized electrode, shaped on the MR-derived primary somatosensory cortical strip, reduced fatigue in all patients, by 26 % in average (p = 0.002), which did not change after sham (p = 0.901). Anodal tDCS over bilateral somatosensory areas was able to relief fatigue in mildly disabled MS patients, when the fatigue-related symptoms severely hamper their quality of life. These small-scale study results support the concept that interventions modifying the sensorimotor network activity balances could be a suitable non-pharmacological treatment for multiple sclerosis fatigue.
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