Journal
JOURNAL OF NEUROLOGY
Volume 260, Issue 2, Pages 620-626Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-012-6688-y
Keywords
Bacterial infections; Central nervous system; Herpes encephalitis; HIV-associated dementia (MesH term AIDS dementia complex); Amyloid; Tau protein
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Funding
- Sahlgrenska Academy at the University of Gothenburg [ALFGBG-11067]
- Swedish Research Council [2007-7092]
- Goteborg Medical Society
- Merck and Company
- Sanofi Pasteur MSD
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The cerebrospinal fluid (CSF) biomarker profile in Alzheimer's disease (AD) is characterized by decreased beta amyloid (A beta(1-42)), increased total and hyperphosphorylated tau (t-tau and p-tau, respectively), which is a useful diagnostic tool and gives insight in the pathogenesis of AD. It is of importance to study how these biomarkers react in other CNS diseases; therefore, we decided to analyse amyloid and tau biomarkers in different CNS infections. We also included analysis of soluble amyloid precursor proteins (sAPP alpha and -beta). CSF A beta(1-42), sAPP alpha and -beta, t-tau and p-tau were analysed in bacterial meningitis (n = 12), Lyme neuroborreliosis (n = 13), herpes simplex virus type 1 (HSV-1) encephalitis (n = 10), HIV-associated dementia (HAD) (n = 21), AD (n = 21) and healthy controls (n = 42). Concurrent with AD, A beta(1-42) was decreased in all groups except neuroborreliosis compared to controls. HSV-1 encephalitis, bacterial meningitis and HAD showed lower concentrations of sAPP alpha and -beta compared to AD. T-tau was increased in AD and HSV-1 encephalitis compared to all other groups. P-tau was higher in AD and HSV-1 encephalitis compared to bacterial meningitis, HAD and control. Decreased CSF A beta(1-42), sAPP alpha and -beta in various CNS infections imply an effect of neuroinflammation on amyloid metabolism which is similar in regard to AD concerning A beta(1-42), but differs concerning sAPP alpha and -beta. These results clearly indicate different pathologic pathways in AD and infectious CNS disease and may provide help in the differential biomarker diagnostics. Increased p-tau in HSV-1 encephalitis probably reflect acute neuronal damage and necrosis.
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