Journal
JOURNAL OF NEUROLOGY
Volume 255, Issue 11, Pages 1652-1656Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-008-0945-0
Keywords
amyotrophic lateral sclerosis; iron metabolism; serum; ferritin
Categories
Funding
- Medical Research Council UK
- Motor Neurone Disease Association UK
- Midland Neuroscience Teaching and Research Fund
Ask authors/readers for more resources
Iron misregulation promotes oxidative stress, a proposed pathological mechanism in neurodegenerative disease. The aim of this study was to evaluate serum iron metabolism indicators in 60 amyotrophic lateral sclerosis (ALS) patients and 44 age matched controls. Serum ferritin levels were significantly increased in ALS patients compared to controls (p < 0.001), while no differences in the levels of serum iron, transferrin, iron saturation or total iron binding capacity were found. Likewise no differences in C reactive protein (CRP) or caeruloplasmin were detected, suggesting that the elevated ferritin levels in ALS did not merely indicate an acute phase response. The increased ferritin level may reflect a general increase in stored iron or be a consequence of ongoing muscle degeneration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available